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Commence the madness!
First Round (Round of 64), Thursday, March 16
| Games (Round of 64) | Date | Game Site | Time (ET) | Network |
(5) Notre Dame vs. (12) Princeton 
|
March 16 | Buffalo | 12:15 p.m. | CBS |
| (5) Virginia vs. (12) UNCW |
March 16 | Orlando | 12:40 p.m. | truTV |
| (4) Butler vs. (13) Winthrop |
March 16 | Milwaukee | 1:30 p.m. | TNT |
| (1) Gonzaga vs. (16) S. Dakota St. |
March 16 | Salt Lake City | 2:00 p.m. | TBS |
| (4) West Virginia vs. (13) Bucknell |
March 16 | Buffalo | 2:45 p.m. | CBS |
| (4) Florida vs. (13) E. Tennessee St. |
March 16 | Orlando | 3:10 p.m. | truTV |
| (5) Minnesota vs. (12) MTSU |
March 16 | Milwaukee | 4:00 p.m. | TNT |
| (8) Northwestern vs. (9) Vanderbilt |
March 16 | Salt Lake City | 4:30 p.m. | TBS |
| (6) Maryland vs. (11) Xavier |
March 16 | Orlando | 6:50 p.m. | TNT |
| (1) Villanova vs. (16) Mt. St Mary's |
March 16 | Buffalo | 7:10 p.m. | CBS |
| (7) St. Mary's (CA) vs. (10) VCU |
March 16 | Salt Lake City | 7:20 p.m. | TBS |
| (4) Purdue vs. (13) Vermont |
March 16 | Milwaukee | 7:27 p.m. | truTV |
| (3) FSU vs. (14) Florida Gulf Coast |
March 16 | Orlando | 9:20 p.m. | TNT |
| (8) Wisconsin vs. (9) Virginia Tech |
March 16 | Buffalo | 9:40 p.m. | CBS |
| (2) Arizona vs. (15) North Dakota |
March 16 | Salt Lake City | 9:50 p.m. | TBS |
| (5) Iowa State vs. (12) Nevada |
March 16 | Milwaukee | 9:57 p.m. | truTV |